The NFL season may be very practically right here. The Buccaneers and Cowboys will kickstart Week 1 on Sept. 9, and NFL bettors are desirous to get in on the motion. After spending the 2021 offseason poring over the Week 1 matchups intimately and attempting to determine high quality underdogs and undervalued groups to belief towards the unfold, they’re going to lastly get to see if their bets come to fruition.

This yr, the early-season outcomes should not be fairly as unpredictable as they had been in 2020. Groups truly bought to play preseason video games in 2021. Whereas many groups rested their starters, bettors might at the least glean some insights from the video games and bought to see a handful of outdated faces in new locations. The most important one which followers have but to see is Matthew Stafford with the Rams.

NFL WEEK 1 PICKS: Towards the unfold | Straight-up predictions

Bettors additionally bought a preview of the rookie quarterbacks this yr. As such, they will not be flying blind in the event that they need to belief Trevor Lawrence or Zach Wilson in Week 1. They know what they’re stepping into.

On the early phases of the season, there aren’t a whole lot of impactful accidents that might impact Week 1 spreads. Saquon Barkley (knee) is among the many greatest, as he’s working his means again from a torn ACL he suffered in Week 2 final season. Amongst quarterbacks, the statuses of Joe Burrow and Carson Wentz will bear watching. Burrow logged three snaps within the preseason getting back from an ACL tear of his personal. The Bengals consider he’ll be capable to play in Week 1, but when he is restricted at observe, that might change.

In the meantime, Wentz is coping with a foot damage that can preserve him out 5 to 12 weeks. If he can return on the decrease finish of that timeline, he might play in Week 1. If he wants further time, Jacob Eason is likely to be pressured to start out.

For extra skilled NFL predictions, take a look at Sporting Information’ picks straight up and towards the unfold for Week 1.

MORE: Listed below are the perfect bets to win Tremendous Bowl 56

NFL odds for Week 1

Under are the newest Week 1 NFL odds, together with level spreads, cash strains and over-under totals for each sport, in response to FanDuel Sportsbook.

Final up to date: Wednesday, Sept. 8

NFL level spreads Week 1

NFL cash strains Week 1

NFL over-unders Week 1

NFL finest bets for Week 149ers (-7.5) at Lions

As of this writing, the 49ers are tied for the largest Week 1 favourite with the Buccaneers. That stated, San Francisco is the extra interesting of the 2 and stands out as the most interesting staff to soak up Week 1.

The 49ers had been top-of-the-line groups within the NFL throughout the 2019 season however regressed badly in 2020 resulting from numerous accidents. They’re now wholesome and may have an opportunity to select aside a lackluster Lions protection.

Jimmy Garoppolo, Deebo Samuel, George Kittle, Brandon Aiyuk and Raheem Mostert are all wholesome, so they need to key a stable offensive efficiency. Defensively, the 49ers ought to be capable to include Jared Goff. They’ve expertise dealing with the previous Rams passer, and whereas he has 14 passing TDs towards the 49ers — probably the most he has towards anyone staff — he additionally has six interceptions, 5 fumbles and only a 3-5 document towards the Niners.

It will likely be more durable for Goff to maintain Detroit within the sport given the dearth of expertise they’ve surrounding him, particularly since D’Andre Swift is banged up. The 49ers ought to win this sport by double digits, even on the highway.

Washington (+1) vs. Chargers

Washington being a house underdog would not fairly appear proper, even towards a well-built staff just like the Chargers. It is true that Washington did not carry out effectively within the preseason and averaged simply 11 factors per sport. Nonetheless, their beginning protection — and Chase Younger, particularly — seemed superb. And if William Jackson III can get wholesome, he can have a big effect on the secondary.

If Washington’s protection exhibits up, it might make life tough for Justin Herbert and the Chargers. Los Angeles opted to sit down most of its starters throughout the preseason, so Herbert hasn’t seen in-game motion since Week 17. He might be gradual out of the gate towards a great protection consequently, particularly if his new-look offensive line takes a while to jell. Add in that this will probably be Brandon Staley’s first regular-season sport as an NFL head coach and Washington appears very interesting as an underdog.

Cardinals (+3) at Titans

The Titans could have a powerful offense, however their protection continues to be a piece in progress. Their entrance seven ought to be higher after including Bud Dupree throughout the offseason, however their secondary continues to be an issue. Their high corners are Janoris Jenkins, rookie Caleb Farley and second-year participant Kristian Fulton, who had his share of points in 2020.

The Cardinals have the firepower wanted to make that an issue for the Titans’ protection, as their receivers can reap the benefits of the weak spot at cornerback whereas Kyler Murray will be capable to mitigate the Tennessee move rush along with his mobility. Their protection ought to be higher after including J.J. Watt and Zaven Collins to the fold, so they might win this one outright.

Taking Arizona as three-point underdogs looks like a no brainer. In any case, they practically made the playoffs final yr and doubtless would have if Murray hadn’t been dinged up.